The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine.

Agnese Donadei,Cristiana Balocchi,Francesca Mancini,Daniela Proietti,Simona Gallorini,Derek T O'Hagan,Ugo D'Oro,Francesco Berti,Barbara C Baudner,Roberto Adamo

European Journal of Pharmaceutics and Biopharmaceutics（2016）

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摘要

Conjugation of a small molecule immunopotentiator to antigens has been proposed to deliver the ligand to the receptor, localize its action and minimize systemic inflammation. However, the effect of conjugation of Toll like receptor 7 agonists (TLR7a) on the immunogenicity of carbohydrate-based vaccines is unknown.

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关键词

TLR7 agonist,Glycoconjugates,Adjuvants,Carbohydrate-based vaccines,Meningitidis

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