Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor.

Daisuke Nishiyama,Yuki Sakai,Haruka Sekiguchi,Hiroaki Chiba,Ryosuke Misu,Shinya Oishi,Nobutaka Fujii,Hiroaki Ohno

CHEMICAL & PHARMACEUTICAL BULLETIN（2016）

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摘要

A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to kappa- (KOR) and mu-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC50=3.9-11 mu m) without binding to MOR.

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关键词

kappa-opioid receptor,opioid,benzofuran,morphine

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