Urinary inflammatory cytokines as indicators of kidney damage in type 2 diabetic patients.

Manuela Borges Sangoi,José Antonio M de Carvalho,Etiane Tatsch,Bruna S Hausen,Yãnaí S Bollick,Sílvia W K Londero,Thiago Duarte,Rogério Scolari,Marta M M F Duarte,Melissa O Premaor,Fabio V Comim,Maria B Moretto,Rafael N Moresco

Clinica Chimica Acta（2016）

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摘要

•Diabetic kidney disease (DKD) is characterized by persistent albuminuria.•Some patients with diabetes have renal dysfunction even in a normoalbuminuric range.•Inflammatory cytokines play a role in the development and progression of DKD.•Urinary levels of IL-1 and IL-6 are altered in diabetic normoalbuminuric patients.•Urinary inflammatory cytokines are able to identify DKD in type 2 diabetes patients.

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关键词

DKD,T2DM,IL,TNF-α,IFN-γ,uAlb,uACR,HbA1c,CKD-EPI

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