Value of serum human epididymis secretory protein 4 as a marker for differential diagnosis of malignant and benign gynecological diseases of patients in southern China.

•HE4 could be used to differentiate the benign and malignant gynecological diseases.•ROMA could be applied to predict ovarian cancer from benign gynecological diseases.•ROMA could be predicted of endometrial cancer from benign gynecological diseases.•Combination of HE4, CA125, and ROMA improved differentiate of gynecological diseases.