l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines.

Cristiane Tavares, Thaís Maciel,Sandra Burin,Luciana Ambrósio,Sandro Ghisla,Suely Sampaio,Fabíola Castro

Revista Brasileira de Hematologia e Hemoterapia（2016）

引用 15|浏览13

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摘要

l-Amino acid oxidase from C. rhodostoma snake venom is a potential antineoplastic agent against HEL 92.1.7 and SET-2 JAK2V617F-positive cells as it activates the extrinsic apoptosis pathway.

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关键词

Myeloproliferative neoplasms,Apoptosis,l-Amino acid oxidase,Calloselasma rhodostoma,Janus kinase 2 mutation

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