Direct Acting Antiviral Therapy Is Curative For Chronic Hepatitis C/Autoimmune Hepatitis Overlap Syndrome

Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/ autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting antiviral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.