GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

    Cancer discovery, Volume 6, Issue 8, 2016, Pages 886-99.

    Cited by: 39|Bibtex|Views2|Links
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    Abstract:

    The role of stroma in pancreatic cancer is controversial. Here, we provide the first characterization of MSCs within the human PDA microenvironment and demonstrate that CA-MSCs promote tumorigenesis through the production of GM-CSF. These data identify a novel cytokine pathway that mediates mesenchymal-epithelial cross-talk and is amenabl...More

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