Mono- and polyprotic buffer systems in anion exchange chromatography of influenza virus particles.

Judith Vajda,Dennis Weber,Sabine Stefaniak,Boris Hundt, Tanja Rathfelder,Egbert Müller

Journal of Chromatography A（2016）

引用 14|浏览1

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摘要

•Capturing of whole influenza virus particles from cell culture with AEX.•Polyprotic ions support multimodal interactions between a polyamine ligand and H1N1.•A polyamine ligand binds with pseudo-affinity to an ion channel of influenza.•Polyprotic buffers stabilize H1N1 during chromatography.•SEC provides an alternative process analytical technology for whole virus particles.

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关键词

Pandemic influenza virus,Multimodal chromatography,Anion exchange chromatography,Polyprotic acids,Whole virus particle capturing,Pseudo affinity chromatography

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