PSMA targeted docetaxel-loaded superparamagnetic iron oxide nanoparticles for prostate cancer.

Prashanth K B Nagesh, Nia R Johnson,Vijaya K N Boya,Pallabita Chowdhury,Shadi F Othman,Vahid Khalilzad-Sharghi,Bilal B Hafeez,Aditya Ganju,Sheema Khan,Stephen W Behrman,Nadeem Zafar,Subhash C Chauhan,Meena Jaggi,Murali M Yallapu

Colloids and Surfaces B: Biointerfaces（2016）

引用 109|浏览13

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摘要

•Docetaxel was successfully loaded in cyclodextrin layers of SPION formulation.•SPION-Dtxl exhibits cellular internalization and delivery in prostate cancer cells.•SPION-Dtxl induces superior anti-cancer effects in PC cells.•J591 mAb was conjugated via SHN-PEG-PEG linker onto SPION-Dtxl formulation.•PSMA targeted J591-SPION-Dtxl promotes specific targeting of prostate cancer cells.

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关键词

Magnetic nanoparticles,Drug delivery,Prostate cancer,Targeted delivery

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