Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Kimberly Page,Ali Mirzazadeh,Thomas M Rice,Jason Grebely,Arthur Y Kim,Andrea L Cox,Meghan D Morris,Margaret Hellard,Julie Bruneau,Naglaa H Shoukry,Gregory J Dore,Lisa Maher,Andrew R Lloyd,Georg Lauer,Maria Prins,Barbara H McGovern

OPEN FORUM INFECTIOUS DISEASES（2016）

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摘要

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.

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acute infection,alanine aminotransferase,hepatitis C virus,IFNL4,jaundice

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