Benzo(a)pyrene induces interleukin (IL)-6 production and reduces lipid synthesis in human SZ95 sebocytes via the aryl hydrocarbon receptor signaling pathway.

Tingting Hu,Zhanyan Pan,Qian Yu,Xiaohui Mo,Ningjing Song,Min Yan,Christos C Zouboulis,Longqing Xia,Qiang Ju

Environmental Toxicology and Pharmacology（2016）

引用 26|浏览6

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摘要

•Benzo(a)pyrene (BaP) could activate AhR signaling pathway in SZ95 sebocytes.•BaP induced interleukin-6 secretion in SZ95 sebocytes through AhR signaling pathway.•BaP inhibited lipogenesis of SZ95 sebocytes through AhR signaling pathway.

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关键词

SZ95 sebocytes,Benzo(a)pyrene,AhR,IL-6,Acne,Acne inversa

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