Elevated glucose levels impair the WNT/β-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer.

•AN3CA and HEC-1-B cells showed high β-catenin expression under elevated glucose levels.•Both cell lines also exhibited an increase in O-GlcNAcylation levels.•β-catenin expression increases via activation of HBP in both cell lines.•Glucose-induced β-catenin elevation triggers the transcription of target genes.