Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice.

•Both dimorphic (D) and C region fragments of the two allelic families of MSP2 are immunogenic.•The fine specificity and intensity of the antibodies responses are dependent on mouse strains and adjuvants.•The major epitopes are restricted to the sequences comprising the last 8aa of D and first 12aa of C of the two allelic families and the first 20aa of the C region.•Strong immune responses were associated with GLA-SE adjuvant and its combination with other TLR agonists.•And elicited antibodies are active in ADCI for Plasmodium falciparum growth inhibition.