17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency.

Neuroscience(2016)

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摘要
•Co-administration of 17β and NAC is efficient to block the degeneration of DA neurons.•17β/NAC synergism enhances neuroprotection of DA neurons “in vivo”.•The antioxidant effect of 17β is enhanced in the presence of NAC (glutathione precursor).
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关键词
17β-estradiol,BDNF,DA,GSH,MDA,MPP+,NAC,PBS,PD,SN,SNpc,TH
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