Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans.

Ossyneidee Gutiérrez-Álvarez,Ismael Lares-Asseff,Carlos Galaviz-Hernández,Elio-Aarón Reyes-Espinoza,Horacio Almanza-Reyes,Martha Sosa-Macías,Isaías Chairez Hernández,José-Manuel Salas-Pacheco,Claudia E Bailón-Soto

Drug metabolism and personalized therapy（2016）

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摘要

The MTHFR A1298C CC genotype was associated with an increased risk of developing childhood ALL. However, a decreased risk to ALL with the combination of MTHFR 677CC+1298AC genotypes was found.

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