Aspergillus mediastinitis after cardiac surgery.

•Aspergillus mediastinitis is a very rare complication after cardiac surgery.•The prognosis is extremely poor, both in immunocompetent and immunocompromised patients.•Culture-negative or indolent sternal wound infection should suggest this complication.•Optimal treatment relies on surgical debridement and antifungal therapy.•Antifungal treatment should include amphotericin B or voriconazole.