A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation.

Andreas Schaefer,Yvonne Schneeberger,Justus Stenzig,Daniel Biermann,Marisa Jelinek,Hermann Reichenspurner,Thomas Eschenhagen,Heimo Ehmke,Alexander P Schwoerer

PloS one（2017）

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摘要

Combination of TAC and hHTx in rats offers an economic and reproducible small animal model enabling serial examination of mechanical unloading in a truly hypertrophic and failing heart, representing the typical pressure overloaded and dilated LV, occurring in patients with moderate to severe heart failure.

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