Impact of 3'UTR genetic variants in PCSK9 and LDLR genes on plasma lipid traits and response to atorvastatin in Brazilian subjects: a pilot study.

Tomás Zambrano,Mario Hiroyuki Hirata,Álvaro Cerda,Egidio L Dorea,Gelba A Pinto,Maria C Gusukuma,Marcelo C Bertolami,Luis A Salazar,Rosario Dominguez Crespo Hirata

International journal of clinical and experimental medicine（2015）

引用 36|浏览14

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摘要

The rs14158 SNP contributes to hypercholesterolemia. Also, a putative microRNA regulation may influence HDL-C variability observed in rs17111557 carriers. Cholesterol-lowering response to atorvastatin is not influenced by LDLR and PCSK9 variants.

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关键词

Atorvastatin,LDLR,PCSK9,cholesterol,microRNAs,polymorphism

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