Correction: GPR119 agonist enhances gefitinib responsiveness through lactate-mediatedinhibition of autophagy

Ji Hye Im,Keon Wook Kang,Sun Young Kim,Yoon Gyoon Kim,Yong Jin An,Sunghyouk Park,Byung Hwa Jung,Song-Yi Choi,Jin-Sun Lee,Keon Wook Kang

Journal of experimental & clinical cancer research : CR（2022）

引用 7|浏览10

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摘要

GPR119 agonists reduced mitochondrial OXPHOS and stimulated glycolysis in breast cancer cells, with consequent overproduction of lactate that inhibited autophagosome formation. Because autophagy is crucial for the survival of cancer cells exposed to TKIs, GPR119 agonists potentiated the anticancer effects of TKIs.

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关键词

Autophagy,Breast cancer,Gefitinib,GPR119 agonist,Lactate

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