KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects.

P P Banerjee, L Pang,S S Soldan, S M Miah, A Eisenberg,S Maru,A Waldman,E A Smith, Y Rosenberg-Hasson,D Hirschberg,A Smith, D V Ablashi,K S Campbell,J S Orange

Molecular Immunology（2019）

引用 7|浏览20

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摘要

•NK cell KIR2DL4 interacts with HLA-G on OLs, leading to IFN-γ production by NK cells.•IFN-γ from NK cells reduces myelin protein content from OLs in vitro.•KIR2DL4+ and CD56bright NK cells are higher in number in MS patients.•Patient NK cell-OL conjugates are high in IFN-γ but low in myelin protein content.

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关键词

eNK cell,OL,MAG,MOG,KIR2DL4,HLAG,KIR2DL1,IFN-,MS,WT-KIR2DL4,RG-KIR2DL4

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