Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice.

Brandon L Panaro,Andrew L Coppage,Jacqueline L Beaudry,Elodie M Varin,Kirandeep Kaur,Jack H Lai,Wengen Wu,Yuxin Liu,William W Bachovchin,Daniel J Drucker

Molecular Metabolism（2019）

引用 16|浏览22

暂无评分

摘要

•Acute inhibition of FAP enzyme activity improves glucose tolerance in mice.•Fap knockout mice exhibit normal glucose and lipid tolerance.•Fap knockout mice do not resist obesity after high fat feeding.•Talabostat robustly lowers glucose in a FAP and FGF21-independent manner.•Talabostat, but not CPD60, requires DPP4 to exert its full metabolic activity.

查看译文

关键词

Diabetes,Obesity,Glucose,Body weight,Enzyme,Metabolism

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要