SEC14L2, a lipid-binding protein, regulate HCV replication in culture with inter- and intra- genotype variations.

Rui Costa,Daniel Todt,Francisco Zapatero-Belinchón,Christian Schenk,Olympia E Anastasiou,Andreas Walker,Barbara Hertel, Lejla Timmer,Denisa Bojkova, Maren Ruckert,Christoph Sarrazin,Jörg Timm,Volker Lohmann,Michael P Manns,Eike Steinmann,Thomas von Hahn,Sandra Ciesek

Journal of Hepatology（2019）

引用 7|浏览35

暂无评分

摘要

•SEC14L2 was shown to allow natural HCV isolates to replicate in vitro.•Natural isolates from genotypes 1,2,3 and 4 replicate in cells overexpressing SEC14L2.•Replication does not occur in 100% of the cases and varies with genotype.•SNP rs191341134 causes lower levels of SEC14L2 in the cytosol and lower viral replication.•SNP rs757660 recapitulates the wild-type protein phenotype in vitro and in vivo.

查看译文

关键词

Hepatitis C virus,SEC14L2,Host factors,Polymorphisms,Viral and cellular determinants of HCV replication

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要