Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury.

Guohui Zou,Jinhua Zhu,Zhongyong Liu,Lu Wu,Ri Xu, Hongtao Chen,Peng Deng,Changqing Deng

Prostaglandins & Other Lipid Mediators（2019）

引用 7|浏览3

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摘要

•Restenosis remains the principal problem in percutaneous coronary intervention treatment.•Inflammation mechanism is one of the major core mechanisms in the formation of vascular smooth muscle cells (VSMCs), and it plays an important role in intima hyperplasia and restenosis.•Detoxification and activating blood circulation decoction (DABCD) can inhibit the inflammatory reaction, thereby inhibiting intima hyperplasia and reducing restenosis through inhibition of TLR4/NF-κB signaling pathway.

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关键词

Detoxification and activating blood circulation decoction,PCI operation,Restenosis,VSMCs proliferation,Inflammatory reaction,TLR4/NF-κB

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