Flotillins in the intercalated disc are potential modulators of cardiac excitability

Elise L. Kessler,Leonie van Stuijvenberg,Joanne J.A. van Bavel,Joëlle van Bennekom,Anne Zwartsen,Mathilde R. Rivaud,Aryan Vink,Igor R. Efimov,Alex V. Postma,J. Peter van Tintelen,Carol A. Remme,Marc A. Vos,Antje Banning,Teun P. de Boer,Ritva Tikkanen,Toon A.B. van Veen

Journal of Molecular and Cellular Cardiology（2019）

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摘要

•Flotillin-1 and Flotillin-2 are present in the cardiac intercalated disc•Flotillin knockout decreases protein levels of the sodium channel NaV1.5•Knockdown of Flotillin-2 and -1/2 by siRNAs decreases the peak inward sodium current (INa)•Flotillins seem to affect cardiac excitability

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关键词

Flotillin,Reggie,Desmosome,Intercalated disc,Cardiac excitation,NaV1.5

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