T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

Amalie K Bentzen, Lina Such,Kamilla K Jensen,Andrea M Marquard,Leon E Jessen,Natalie J Miller,Candice D Church,Rikke Lyngaa,David M Koelle,Jürgen C Becker,Carsten Linnemann,Ton N M Schumacher,Paolo Marcatili,Paul Nghiem,Morten Nielsen,Sine R Hadrup

NATURE BIOTECHNOLOGY（2018）

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摘要

The relative affinity of T cell receptors for different peptide–MHCs is measured at high throughput, revealing T cell cross-reactivity.

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关键词

Antigen presentation,Cancer immunotherapy,Computational biology and bioinformatics,Immunological techniques,MHC class I,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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