Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.
Bioorganic Chemistry(2019)
摘要
•Eleven dauricine derivatives were synthesized.•Four compounds displayed significant cytotoxicity against five cancer cells.•Four derivatives are validated to induce autophagy-dependent cell death in HeLa cancer cells.
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关键词
Bisbenzylisoquinoline alkaloids,Dauricine derivatives,Carbamate,Autophagy activator,Anti-cancer
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