Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis.

Rohit Loomba,Anjali Jain,Anna Mae Diehl,Cynthia D Guy,Dana Portenier,Ranjan Sudan,Seema Singh,Claire Faulkner,Lisa Richards,Kelly D Hester,Lauren Okada,Xiao-Jun Li,Larry Mimms,Manal F Abdelmalek

Clinical Gastroenterology and Hepatology（2019）

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摘要

We developed an algorithm that identifies patients with advanced fibrosis from those with mild to moderate fibrosis in patients with NAFLD with an AUROC value of approximately 0.86, based on levels of serum biomarkers. We validated the findings in two separate sets of patients with biopsy-proven NAFLD. The algorithm can be used non-invasively to determine risk of advanced fibrosis in patients with NAFLD.

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关键词

Patient Stratification,NPV,Steatohepatitis,NASH

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