Tri-ortho-cresyl phosphate (TOCP) induced ovarian failure in mice is related to the Hippo signaling pathway disruption

Liaoliao Hu,Tingting Peng,Jian Huang,Tie Su,Ruichen Luo,Yuehui Zheng,Zhisheng Zhong, Peiling Yu, Kun Nie,Liping Zheng

Reproductive Toxicology（2019）

引用 19|浏览12

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摘要

•TOCP impaired ovarian follicle development and ovarian function.•TOCP-induced ovarian failure may be mediated by increasing the expression of both the Hippo pathway and the genes related to ovarian follicle apoptosis.•Hippo-YAP1 over-expression partially reversed the TOCP-induced ovarian impairment.

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关键词

Plasticizer,Tri-ortho-cresyl phosphate,Reproductive toxicity,Ovarian function,Hippo pathway

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