A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation

Jia Xu,Ye Yuan,Ruining Zhang,Yanhui Song,Tianzhuo Sui,Jiaqi Wang, Chonghan Wang,Yujia Chen,Shuwen Guan,Liping Wang

Bioorganic Chemistry（2019）

引用 16|浏览7

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摘要

•DhHP-6 inhibits the aggregation of Aβ1–42 in vitro.•DhHP-6 binds to Aβ1–42 closely at the α-helix and β-sheet structures.•DhHP-6 efficiently protects a transgenic C. elegans model of Alzheimer’s disease.

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关键词

Alzheimer’s disease,Deuterohemin peptide,Amyloid β,Caenorhabditis elegans

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