Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.

Jurriaan M Peters,Anna Prohl,Kush Kapur,Audrey Nath,Benoit Scherrer,Sean Clancy,Sanjay P Prabhu,Mustafa Sahin,David Neal Franz,Simon K Warfield,Darcy A Krueger

Pediatric Neurology（2019）

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摘要

Effects from mTOR overactivity on white matter microstructural integrity in TSC were modified through pharmacologic inhibition of mTOR. These changes sustained over time, were greater with longer treatment and in younger patients during a time of rapid white matter maturation.

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关键词

Children,Tuberous sclerosis complex,Diffusion tensor imaging,Mechanistic target of rapamycin,mTOR

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