Phosphorylation of Serine 305 in Tau Inhibits Aggregation.

Kevin H Strang,Zachary A Sorrentino,Cara J Riffe,Kimberly-Marie M Gorion,Niran Vijayaraghavan,Todd E Golde,Benoit I Giasson

Neuroscience Letters（2019）

引用 21|浏览4

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摘要

•The S305E tau phosphomimetic inhibits aggregation and seeding in established cell culture models.•Novel monoclonal antibody 2G2 specific for tau phosphorylated at S305 was established and characterized.•Phosphorylated S305 is not detected in Alzheimer’s disease tau inclusions.

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关键词

Aggregation,Antibody,Inhibition,Phosphorylation,Seeding,Tau

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