Validation of a novel system for co-registration of coronary angiographic and intravascular ultrasound imaging.

•Correlating IVUS images with angiographic findings can be challenging.•We evaluated the utility of a novel co-registration system for IVUS and coronary angiography.•A 3-D virtual catheter trajectory was constructed from separate angiographic imaging runs using bespoke software.•IVUS images were co-registered to angiographic images based on the length of pullback, the 3-D trajectory and the start position of the catheter.•Validation was performed in a spherical phantom model and in vivo in patients undergoing clinically indicated coronary angiography and IVUS.