Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach.

Job Tchoumtchoua,Maria Halabalaki,Evangelos Gikas,Anthony Tsarbopoulos,Nikoletta Fotaki,Lucy Liu,Sangkil Nam,Richard Jove,Leandros A Skaltsounis

Journal of Pharmaceutical and Biomedical Analysis（2019）

引用 4|浏览32

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摘要

•First LC–MS/MS report for determination of 6BIO in mice plasma.•Simple sample treatment method and rapid method for routine analysis.•Full validation of the developed method using FDA, EMA and ICH procedures.•Preliminary pharmacokinetics study of 6BIO in mice.

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关键词

6BIO,Pharmacokinetics,UHPLC-Orbitrap MS,Quantitation,Plasma

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