CLN8 safeguards lysosome biogenesis
NATURE CELL BIOLOGY(2018)
摘要
Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.
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关键词
Lysosomes,Protein transport,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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