Seroconversion of JCV antibodies is strongly associated to natalizumab therapy.

Yara Dadalti Fragoso,Joseph B Bidin Brooks,Audred C Biondo Eboni,Leticia Fezer,Paulo Diniz da Gama,Sidney Gomes,Marcus Vinicius M Gonçalves,Suzana Nunes Machado,Rogerio Rizo Morales,Maria Lucia Vellutini Pimentel,Heloisa Helena Ruocco, Gutemberg Augusto Santos,Simone Scherpenhuijzen,Nise Alessandra Carvalho Sousa

Journal of Clinical Neuroscience（2019）

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摘要

•Infection with JC virus increases the risk of potentially fatal PML.•Natalizumab, used to treat MS, has been implicated in several cases of PML.•Patients with MS who are JCV negative have lower risk of PML.•The use of natalizumab was strongly associated to seroconversion of JCV antibodies.

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关键词

JC virus,Multiple sclerosis,Natalizumab

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