HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape
Journal of hepatology, 2018.
Q80Kasunaprevirglecaprevirvoxilaprevirdirect acting antiviralMore(7+)
Among all clinically relevant hepatitis C virus (HCV) protease inhibitors, voxilaprevir and glecaprevir showed the highest and most uniform activity against cell culture infectious HCV with genotype 1-6 proteases. Naturally occurring amino acid changes at protease position 80 had low fitness cost and influenced sensitivity to simeprevir, ...More
Full Text (Upload PDF)