HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

    Journal of hepatology, 2018.

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    Keywords:
    Q80Kasunaprevirglecaprevirvoxilaprevirdirect acting antiviralMore(7+)

    Abstract:

    Among all clinically relevant hepatitis C virus (HCV) protease inhibitors, voxilaprevir and glecaprevir showed the highest and most uniform activity against cell culture infectious HCV with genotype 1-6 proteases. Naturally occurring amino acid changes at protease position 80 had low fitness cost and influenced sensitivity to simeprevir, ...More

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