Sappanone A prevents hypoxia-induced injury in PC-12 cells by down-regulation of miR-15a

Chunyang Kang,Jian Gao,Mingyang Kang,Xiaoyang Liu,Yao Fu,Libo Wang

International Journal of Biological Macromolecules（2019）

引用 7|浏览7

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摘要

Sappanone A exerted protective activity in PC-12 cells which were stimulated by hypoxia. One of the possible mechanisms of the neuroprotective effect is that: Sappanone A down-regulated the expression of miR-15a, and thus activated Wnt/β-catenin and PI3K/AKT signaling pathways.

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关键词

Sappanone A,Cerebral ischemia,Hypoxia

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