Quantitation of low abundant soluble biomarkers using high sensitivity Single Molecule Counting technology.

Joseph Hwang, Munmun Banerjee,Adam S Venable, Zara Walden, John Jolly, Cathleen Zimmerman, Elizabeth Adkisson,Qiang Xiao

Methods(2019)

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摘要
•Traditional immunoassay methods for protein biomarkers are limited by sensitivity.•New technologies enable Single Molecule Counting of fluorescent markers.•Sensitivity for immunoassays has improved to sub-picomolar range.•This method presents an affordable option for high-sensitive biomarker research.
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关键词
SMC,SMCxPRO,Femtomolar,Sub-picogram,Bead-based assay,cTnI
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