The imbalance of serotonergic circuitry impairing the crop supercontractile muscle activity and the mitochondrial morphology of PD PINK1 B9 Drosophila melanogaster are rescued by Mucuna pruriens.

Paolo Solari,Riccardo Maccioni,Roberto Marotta,Tiziano Catelani,Doriana Debellis,Biancamaria Baroli,Stefania Peddio,Patrizia Muroni,Sanjay Kasture,Paolo Solla,John G Stoffolano,Anna Liscia

Journal of Insect Physiology（2018）

引用 7|浏览40

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摘要

•Drosophila PINK1B9 mutant is a model for Parkinson’s disease.•The adult crop organ is an important and essential part of the gut.•PINK1B9 flies show morphological and functional impairment in the crop muscle.•PINK1B9 flies show an impairment in the 5-HT circuitry.•Mucuna pruriens extract rescues the crop impairment.

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关键词

Drosophila melanogaster,Parkinson's disease,PINK1B9 mutants,5-HT,Phytotherapic preparations,Gastrointestinal system

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