Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).

Jeffrey J Letourneau,Ilana L Stroke,David W Hilbert,Andrew G Cole, Laurie J Sturzenbecker,Brett A Marinelli,Jorge G Quintero,Joan Sabalski,Yanfang Li,Linh Ma, Igor Pechik,Philip D Stein,Maria L Webb

Bioorganic & Medicinal Chemistry Letters（2018）

引用 7|浏览19

暂无评分

摘要

•Highly potent C. diff. toxin B (TcdB) inhibitors identified.•Improved plasma stability enabled compound progression into in vivo models of CDI.•Compound 11d efficacious in hamster survival model of CDI upon oral dosing.

查看译文

关键词

Clostridium difficile,Toxin,TcdB,Inhibitor,Benzodiazepinedione

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要