Respiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge.

Brian E Gilbert,Nita Patel,Hanxin Lu,Ye Liu,Mimi Guebre-Xabier,Pedro A Piedra,Gregory Glenn,Larry Ellingsworth,Gale Smith

Vaccine（2018）

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摘要

•RSV F nanoparticle vaccine elicits protection against palivizumab-resistant RSV.•Adjuvanted vaccine elicits anti-F IgG that binds F protein with higher affinity.•Nanoparticle vaccine elicits antibodies targeting multiple neutralizing epitopes.

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关键词

Respiratory syncytial virus,Palivizumab-resistant mutant RSV,Fusion glycoprotein,Nanoparticle vaccine,Cotton rat

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