Molecular cytogenetics of the micronucleus: Still surprising.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2018）
摘要
•Micronuclei derive from both clastogenicity and missegregation mechanisms.•Several mutagens are able to induce MN by both mechanisms.•Micronuclei are at the origin of the extensive chromosome shattering named chromothripsis.•Damaged micronuclear DNA extruded in the cytoplasm activates innate immunity.
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关键词
MN,cGAS,STING,IFN-I,NF-κB,NHEJ,MMBIR
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