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Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau.

Nina Rosenqvist,Ayodeji A Asuni,Christian R Andersson,Søren Christensen,Justus A Daechsel,Jan Egebjerg,Jeppe Falsig,Lone Helboe, Pia Jul,Fredrik Kartberg,Lars Ø Pedersen,Einar M Sigurdsson,Florence Sotty,Karsten Skjødt,Jeffrey B Stavenhagen,Christiane Volbracht,Jan T Pedersen

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2018）

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摘要
Targeting pS396-tau with an antibody like C10.2 may provide therapeutic benefit in AD and other tauopathies.
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关键词
Anti-tau antibodies,Phospho-serine 396,Tau seeding,Monoclonal antibody,C10.2,D1.2,C5.2,C8.3
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