Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

Hailong Li,Zhen Sun,Wenting Wu,Xuan Wang,Mingqiang Zhang,Xiaojie Lu,Wenge Zhong,Dongcheng Dai

Organic Letters（2018）

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摘要

The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized pyridazine products are selected for subsequent DNA-compatible Suzuki–Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis.

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