Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules.

Crisbel M Artuz,Alexander J Knights,Alister P W Funnell,Thomas J Gonda,Katya Ravid,Richard C M Pearson,Kate G R Quinlan,Merlin Crossley

Biotechnology Reports（2018）

引用 4|浏览24

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摘要

•GATA1 and FLI1 switch on the endogenous platelet factor 4 (Pf4) gene in fibroblasts.•Pf4 expression is maintained and increases over time.•PF4 protein is secreted and readily collected.•A new technology for the g0065neration of important biomolecules in heterologous cells.

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关键词

Platelet factor 4,Reprogramming,Megakaryocyte,Fibroblast

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