Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma.

Heleen Scheerens,Ashley Smith,Olga Li,Lee Honigberg,Jeffrey M Harris,Gabriele Holtappels,Claus Bachert

The Journal of allergy and clinical immunology（2018）

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摘要

A novel PCR assay detected IgE M1 prime transcripts in nasal polyps of patients with CRSwNP and asthma, confirming that IgE switching occurred and membrane IgE-expressing B cells were resident at mucosal sites.

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