6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat.

Débora F Gonçalves,Aline A Courtes,Diane D Hartmann,Pamela C da Rosa, Débora M Oliveira,Félix A A Soares,Cristiane L Dalla Corte

NeuroToxicology（2019）

引用 13|浏览9

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摘要

•Parkinson model with 6-hydroxydopamine shows brain-region specific response.•Mitochondrial bioenergetics differs among brain region exposed to 6-hydroxydopamine.•Striatum exposed to 6-hydroxydopamine presents the higher mitochondrial damage.•Striatum and hippocampus has no mitochondrial adaptive response to 6-hydroxydopamine.•Cortex presents mitochondrial compensatory response due to 6-hydroxydopamine damage.

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关键词

Parkinson disease,Neurodegenerative disease,Mitochondrial function,High-resolution respirometry,ROS production

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