The double stranded RNA analog poly-IC elicits both robust IFN-λ production and oncolytic activity in human gastrointestinal cancer cells.

Chantal Bou-Hanna,Anne Jarry,Jean-François Mosnier,Céline Bossard,Christian L Laboisse

Oncotarget（2018）

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摘要

Our demonstration that poly-IC-induced concomitant recapitulation of two innate functions of normal intestine, i.e. IFN-λ production and cell death, by human gastrointestinal cancer cells opens new perspectives in gastrointestinal cancer treatment.

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关键词

IFN-λ,dsRNA/poly-IC,human gastrointestinal cancer,immunoadjuvant,oncolysis

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