Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

Carol H Hu,Tammy C Wang,Jennifer X Qiao,Lauren Haque,Alice Y A Chen,David S Taylor, Xiaohong Ying,Joelle M Onorato,Michael Galella,Hong Shen,Christine S Huang, Nathalie Toussaint,Yi-Xin Li,Lynn Abell,Leonard P Adam,David Gordon,Ruth R Wexler,Heather J Finlay

Bioorganic & Medicinal Chemistry Letters（2018）

引用 3|浏览39

暂无评分

摘要

•A series of tetrahydropyrimidinedione EL inhibitors was identified.•New compounds showed measurable EL inhibition in human serum.•Optimization led to 4a with micromolar human serum potency and 3g with acceptable mouse PK.

查看译文

关键词

Endothelial lipase (EL) inhibitors,Tetrahydropyrimidinedione (THP),High density lipoprotein cholesterol (HDL-C),Atherosclerosis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要