Simultaneous determination of FLZ and its metabolite (M1) in human plasma and urine by UHPLC-MS/MS: Application to a pharmacokinetic study.

Cheng Cui,Rui Chen,Ji Jiang, Rui Liu,Wei Wang,Qian Zhao,Pei Hu

Journal of Pharmaceutical and Biomedical Analysis（2019）

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摘要

•A rapid and sensitive UHPLC-MS/MS method was developed for the simultaneous determination of FLZ and M1.•The method was fully validated and successfully applied to a first-in-human clinical study.•The PK profiles and excretory fraction in urine were obtained in Chinese healthy subjects for the first time.

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关键词

FLZ,Parkinson’s disease,Human plasma and urine,UHPLC-MS/MS

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